What is PRP?
Platelet-rich plasma(PRP) is a new technological advance that has been used in many different forms. It’s also been called a “blood cell therapy.” Most recently, in the advancement of assistive reproductive technologies.
The procedure is pretty simple. By drawing your blood into a sterile syringe, our laboratory technologists take your blood and spin it in a centrifuge to separate the red blood cells from a platelet concentrate. The red blood cells are removed from this and used to treat various different conditions. The process itself takes roughly 30 minutes. Since you are using your own blood to do the procedure, there is little risk of allergy or rejection with the treatment.
Endometrial Lining and PRP:
Many studies have been conducted on how PRP can help one’s endometrial lining. Certain growth factors from the platelets have helped women increase there endometrial lining thus allowing for a better outcome in IVF procedures.
Endometrial lining is a key factor in pregnancy and lives birth outcome. A study conducted in 2015 showed that women treated with PRP, who had previously failed endometrial lining growth after conventional estrogen therapy treatments, had great success with PRP therapy. Out of five patients that had exceptionally poor lining growth, four of them continued to have a successful pregnancy. You can see the increased lining of the endometrium in the pic below.
(A) Lining prior to treatment. (B) Lining after round 1 of PRP (C) Lining after round 2 of PRP (D) Intrauterine sac at 6 weeks pregnancy
Chang Y, Li J, Chen Y, et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. International Journal of Clinical and Experimental Medicine. 2015;8(1):1286-1290.
Ovarian Rejuvenation and PRP:
Women that have experienced premature ovarian failure or early menopause can utilize ovarian rejuvenation in order to help use their own eggs to have a child. The procedure is to take the platelet rich plasma with the growth factors from the stem cells taken from your own body and inject it into the ovaries which have diminished or completely stopped making eggs. The PRP will then cause your body to “heal itself” with the stem cells that have been formed to try to “reactivate” your ovary by repairing the tissues and possibly inducing folliculogenesis.
White YAR, Woods DC, Takai Y, Ishihara O, Seki H, Tilly JL. Oocyte formation by mitotically active germ cells purified from ovaries of reproductive age women. Nature medicine. 2012;18(3):413-421. doi:10.1038/nm.2669.
Interested in learning more about these breakthrough procedures? Contact NCCRM at 919-233-1680 and schedule an appointment today with our fertility experts.