Patient Resources

What Causes Premature Ovarian Failure

There are a lot of factors that go into the inability to have children. Ovaries eventually stop producing ovum, usually at the beginning of menopause, but this can occur earlier in life for some. This is called premature ovarian failure, or primary ovarian insufficiency (POI). At NCCRM, a clinic for reproductive medicine in NC, we can aid you in figuring out why your ovaries have stopped producing eggs and provide options for treatments.

Genetic Disorders

Genetic polymorphisms, abnormalities in chromosomes, and single-gene mutations have all been proven to have an impact on premature ovarian failure. If the patient has a typical X chromosome but the other is altered, this could cause problems when the time to reproduce comes around. While this seems scary to those who are going through it, there are ways to still have the family the patients desire with North Carolina reproductive medicine.

Autoimmune Diseases

About 20%-30% of premature ovarian failure cases are related to autoimmune diseases. Some patients have an immune system that produces antibodies that destroy ovarian tissues, causing them to be unable to produce ovum and follicles to fail. Treatments for this could involve in-vitro fertilization and other fertility treatments, which are offered by your local clinic for reproductive medicine in NC.


Toxins in the body can have a major impact on one’s ability to procreate. Called toxin-induced ovarian failure, they can damage the genetic material in cells. Toxins include:

  • Cigarette smoke
  • Chemicals
  • Pesticides
  • Viruses
  • Air pollution

Your North Carolina reproductive medicine clinic can inform patients of specific toxins for where they live, but patients should do their best to avoid toxins if they are trying to conceive.

NCCRM | Reproductive Medicine in NC

While it can be confusing and frustrating for those who are having trouble conceiving, NCCRM is ready to help. Our staff is dedicated to curating a treatment plan that suits the patient and their family’s needs. For more information about our clinic for reproductive medicine in NC, please visit our website.

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