Treatment Options

Recipient Couples

Egg Recipient Application/Screening Form

Click here to download form.Split_Donor_Box

Please print, fill out and send to:
NCCRM Donor Program
400 Ashville Ave.; Suite 200
Cary, NC 27518

To see our current list of egg donor profiles, click here.

NCCRM has one of the largest donor IVF programs on the East Coast. Our location, with proximity to three major university centers and a young population, provides a great donor pool. Our recipients come from all over this country, Europe, Asia and the Middle East.

The recipient couple visits our center only once prior to their embryo transfer. During this visit, a thorough history is attained, a physical, and a saline ultrasound of the uterus is performed. The husband will provide a sperm sample for cryopreservation. The couple also will undergo a psychological evaluation by our psychiatrist who delves into the issues this couple will face in deciding to use donor eggs for pregnancy. The couple also will attend an education session about the medications and the different aspects of the cycle. The couple will then turn in their desires in a donor who will be chosen to match the wife physically (eye color, hair color, etc.) and match the husband’s family history genetically. For example, if the husband has a poor family history for certain conditions such as heart disease, a donor with minimal or no heart disease history would be chosen. The matching process usually takes two to three months. Once the match is made, the donor will be monitored in our center while the recipient will be monitored in her home town by her gynecologist or at NCCRM.

Details of Donation Program

If the recipient woman has ovarian function, her ovaries will be medically inactivated. If she does not have ovarian function, this treatment is not required. The woman will take natural female hormone injections to prepare her uterus for placement of embryos.


The recipient and her husband should arrive in Cary the day before retrieval in order that fresh semen can be used for fertilizing the donor oocytes. It is essential that the husband’s sperm be available 4 -5 hours before the time required for insemination, or about 2 hours after retrieval. The husband will be instructed for proper collection of the semen sample. Since collection can sometimes be difficult under stress or the husband is unable to be present at the time of retrieval, a back-up sample will be cryopreserved prior to retrieval.

Maturation and Fertilization of the Oocytes

The oocytes are inseminated with the recipient’s husband’s sperm. The embryos obtained are cultured for approximately 72 hours, at which time they are transferred into the recipient’s uterus.

Transfer of Fertilized Oocytes into the Recipient

Transfer is accomplished by means of a small catheter. The procedure, which is usually simple and painless, is performed without anesthesia under ultrasound guidance. Therefore, you will be asked to come to the transfer with a full bladder. The recipient lies on her back in the operating room adjacent to the embryology laboratory where the embryo has been prepared. The recipient remains in bed in the center for 30 minutes, then returns to her lodging and remains in bed for 24 hours. Following the transfer, implantation may occur and a pregnancy may ensue. However, as in natural reproduction, many fertilized oocytes do not survive.

Post-Transfer Care for the Recipient

One or two days after transfer, the recipient may return home. She will continue hormonal support. Injections may be administered by the recipient’s husband or another qualified person and should be continued at least until the pregnancy test is done in two weeks. If the test is positive, hormonal support will continue for ten weeks. Women who achieve pregnancy will be referred back to their own obstetrician/gynecologist.

The NCCRM Program is a Team Effort

The patients of the program will be cared for by a team of specially-trained gynecologists and nurses, and this team is supported by a laboratory team that specializes in endocrinology, andrology, and embryology. This team approach coordinates clinical practice with assisted reproductive technologies to provide leading edge care in all facets of fertility.


Since the donor is compensated for her participation in the program, you will be required to cover the donor’s costs, and the cost of her treatment preparatory to egg aspiration. NCCRM operates strictly on a cash basis and regrets that credit cannot be extended. Payment by check, cashier’s check, or Mastercard/Visa credit card is acceptable. On her first visit, the recipient will be asked to arrange payment with our financial counselor. Details of the program costs are available from the financial office of NCCRM.

Additional Information

Medical matters should be discussed with the attending physicians. The program is under the direction and supervision of Sameh Toma, MD, Medical Director of NCCRM and Hugh Hensleigh, Ph.D., Labroratory Director. The Donor Oocyte Nurse Coordinator will answer any questions regarding the program (1-800-933-7202). Consent forms will be provided to the donor and the recipient during the screening process. These will help to clarify the procedure.

Summary and Checklist

The use of anonymously donated sperm for initiation of pregnancy has been common practice in the United States for many years. More recently, the advent of in vitro fertilization and embryo transfer has allowed development of programs for the use of donated oocytes (eggs). At the North Carolina Center for Reproductive Medicine (NCCRM), both anonymous and known donors are used. The evaluation and treatment process is identical for both.

Qualifications for Admission

Recipient and Husband

  • The recipient and donor will remain anonymous unless a known donor is involved.
  • The recipient’s general and psychological health should be normal.
  • The recipient should have a normal uterus or a uterine abnormality, which can be treated and corrected.
  • The recipient’s husband should have a semen analysis adequate for assisted reproduction procedures.
  • Informed consent to participate in the program will be obtained from the recipient and her husband.

Application for Admission to the Program

To be considered for admission to this program, the recipient is requested to send the following materials to the attention of the Donor Oocyte Nurse Coordinator:

  • The downloadable questionnaire, completed in its entirety.
  • Pertinent information from her gynecologist:
  • X-rays and films of the uterus and tubes (hysterosalpingogram)
  • Operative notes of any past surgical procedures, including laparoscopies
  • Results of endometrial biopsies
  • Gynecologist’s final diagnosis of the condition requiring oocyte donation
  • A photograph of the husband and wife
  • Infectious disease testing of husband’s sperm prior to storage of back-up sperm sample for cryopreservation. (Required by FDA)
  • Bring all information to your initial visit

Initial Visit

You and your husband will be asked to come to Cary for a preliminary consultation. You should plan to spend a minimum of five (5) hours in our office for this initial visit. The following activities will occur at this visit:

  • The husband will produce a semen specimen. You must abstain from ejaculation for 3 – 5 days prior to collection of specimen. This sample will be cryopreserved as a back-up sample if the husband is unable to give a fresh sample on the day of egg retrieval.
  • You will meet with the nurse coordinator for an education session.
  • You will be seen by one of the NCCRM physicians for a history and physical. If further laboratory evaluation is required, it will be scheduled at a later time. A saline ultrasound and sounding of the uterus will be performed.
  • A psychological evaluation will be done.
  • You will discuss your plan of care with one of the NCCRM physicians.
  • Finally, you will meet with a financial coordinator to discuss policies.

Information on NCCRM’s Split Donor Program.  Click here.

3rd Party Parenting Presentation by Dr. Sameh K. Toma, Medical Director of NCCRM.

Watch a couple’s story about using an egg donor to build their family. Video is courtesy of the Today Show: